CARDIOX : Cardiovascular effects of traffic-related air pollution

Inhalation study in rat of NO2 alone or in diesel engine emissions

Présentation

The objective of this project was to demonstrate the effects on the cardiovascular system of NO2 alone or as a mixture with other gaseous pollutants emitted by a Euro 4 Diesel engine equipped with a particulate filter. The pollutant emissions, diluted by a factor of 11, were taken upstream and downstream of the particulate filter to assess its impact. The work was organized around four main tasks:

exposure of animals (Wistar rats) and characterization of Euro 4 diesel engine emissions,
evaluation of cardiac and mitochondrial function,
evaluation of cardiac remodeling
evaluation of the global and genome-wide cellular response.

The results are presented and analyzed by considering single (3 hours) or repeated (3 hours / days and 5 days / week for three weeks) exposures to NO2 or all pollutants.

Caractéristiques

Date de mise en ligne: 18/04/2025
Type de document: Synthèse d'expertise
Nb. de pages: 10 P

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Présentation

exposure of animals (Wistar rats) and characterization of Euro 4 diesel engine emissions,
evaluation of cardiac and mitochondrial function,
evaluation of cardiac remodeling
evaluation of the global and genome-wide cellular response.

The results are presented and analyzed by considering single (3 hours) or repeated (3 hours / days and 5 days / week for three weeks) exposures to NO2 or all pollutants.

Liste des documents

Cardiox 2017 summury

PDF - 1.4MB

Caractéristiques

Auteurs: MONTEIL Christelle
LECUREUR Valérie
MULDER Paul
CAZIER Fabrice
UNIVERSITE RENNES
UNIVERSITE ROUEN
ADEME
INSERM
IRSET
ABTE
Public(s): Entreprises et fédérations professionnelles
Type de document: Synthèse d'expertise
Thématique: Mobilité et Transports
Air
Recherche et Innovation
Collection: Expertise
Date d'édition: 01/2017
Date de mise en ligne: 18/04/2025
Nb. de pages: 10 P
Format: pdf/A4
Langue: Anglais
Périmètre de publication: International
National