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CARDIOX : Cardiovascular effects of traffic-related air pollution
Inhalation study in rat of NO2 alone or in diesel engine emissions
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The objective of this project was to demonstrate the effects on the cardiovascular system of NO2 alone or as a mixture with other gaseous pollutants emitted by a Euro 4 Diesel engine equipped with a particulate filter. The pollutant emissions, diluted by a factor of 11, were taken upstream and[…]
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Fiche technique
| Auteurs | MONTEIL Christelle, LECUREUR Valérie, MULDER Paul, CAZIER Fabrice, UNIVERSITE RENNES, UNIVERSITE ROUEN, ADEME, INSERM, IRSET, ABTE |
| Public(s) | Entreprises et fédérations professionnelles |
| Thématique | Recherche et Innovation |
| Air | |
| Mobilité et Transports | |
| Collection | Expertise |
| Date d'édition | 2017/01 |
| Nb. de pages | 10 P |
| Format | pdf/A4 |
| Langue | EN |
| Périmètre de publication | National |
| International |
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The objective of this project was to demonstrate the effects on the cardiovascular system of NO2 alone or as a mixture with other gaseous pollutants emitted by a Euro 4 Diesel engine equipped with a particulate filter. The pollutant emissions, diluted by a factor of 11, were taken upstream and downstream of the particulate filter to assess its impact. The work was organized around four main tasks:
- exposure of animals (Wistar rats) and characterization of Euro 4 diesel engine emissions,
- evaluation of cardiac and mitochondrial function,
- evaluation of cardiac remodeling
- evaluation of the global and genome-wide cellular response.
The results are presented and analyzed by considering single (3 hours) or repeated (3 hours / days and 5 days / week for three weeks) exposures to NO2 or all pollutants.